The TRIPS agreement requires developing nations to establish a restrictive Intellectual property right regime, with exceptions for the safety of public health and the promotion of medication availability. Nevertheless, as high-income countries are determined to increase severe IPRs protection and limit flexibilities, as they are devoted primarily to the establishment of market monopoly at the detriment of competition and ability to pay, limiting medicine accessibility. The paper showed that data exclusivity is successfully imposed through the US FTAs, restricting the introduction of generics, that would impair availability to medications in underdeveloped economies and also constrain price competition. By partaking in such trade agreements, poor nations lose freedom, notably in the health sector. As a result, it is critical that international institutions get increasingly proactive in analysing trade agreements to verify that they do not contradict national charters or global trade accords.